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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

Abstract

OBJECTIVE:

Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression…NCBI

hktadmin 2017-02-22T21:47:29+00:00

Special K, a Hallucinogen, Raises Hopes and Concerns as a Treatment for Depression

It is either the most exciting new treatment for depression in years or it is a hallucinogenic club drug that is wrongly being dispensed to desperate patients in a growing number of clinics around the country…The New York Times

hktadmin 2017-02-22T21:36:19+00:00

Ketamine Advocacy Network

The Ketamine Advocacy Network’s mission is to spread awareness of ketamine therapy for treatment-resistant depression, bipolar, and PTSD, and to make this treatment available and affordable for all who need it. We fulfill our mission by…Ketamine Advocacy Network

hktadmin 2017-02-22T21:33:44+00:00

Yale scientists explain how ketamine vanquishes depression within hours

Many chronically depressed and treatment-resistant patients experience immediate relief from symptoms after taking small amounts of the drug ketamine. For a decade, scientists have been trying to explain the observation first made at Yale University…YaleNews

hktadmin 2017-02-22T21:30:44+00:00

Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment-resistant bipolar depression. The present study sought to replicate this finding in an independent sample… Biological Psychiatry

hktadmin 2017-02-22T18:38:20+00:00

Onetime party drug hailed as miracle for treating severe depression

It was November 2012 when Dennis Hartman, a Seattle business executive, managed to pull himself out of bed, force himself to shower for the first time in days and board a plane that would carry him across the country to a clinical trial at the National Institute of Mental Health (NIMH) in Bethesda… Washington Post

hktadmin 2017-02-22T19:15:33+00:00

What It’s Like to Have Your Severe Depression Treated With a Hallucinogenic Drug

Everyone’s depression is different, but Ted, a 40-year-old resident of Portland, Oregon, describes his as a “continuous dark veil — a foul, dark, awful perspective that informs every moment of your whole life.” He’d tried to treat it with antidepressants, therapy, visits to psychiatrists, “the whole nine,” but although the antidepressants kept him functional… Science of US

hktadmin 2017-02-22T20:41:39+00:00