Ketamine Relieves Depression By Restoring Brain Connections

Scientists say they have figured out how an experimental drug called ketamine is able to relieve major depression in hours instead of weeks.

Researchers from Yale and the National Institute of Mental Health say ketamine seems to cause a burst of new connections to form between nerve cells in parts of the brain involved in emotion and mood… NPR

2017-02-22T21:59:22+00:00

Novel drugs for depression – A new generation of drugs could change the way depression is treated

IT STARTED out as LY110141. Its inventor, Eli Lilly, was not sure what to do with it. Eventually the company found that it seemed to make depressed people happier. So, with much publicity and clever branding, Prozac was born. Prozac would transform the treatment of depression and become the most widely prescribed antidepressant in history. Some users described it as “bottled sunshine”. It attained peak annual sales (in 1998) of $3 billion and at the last count had been used by 54m people in 90 countries. And, along the way, it embedded into the public consciousness a particular idea about how depression works.. The Economist

2017-02-22T21:55:16+00:00

How Ketamine Infusions Saved My Life

I’m going to die soon. For months, this is what the voice inside my head told me, repeating over and over. I was plagued by a deep depression, an eating disorder, and drug addiction. I had tried everything from therapy to shock treatments to alleviate my pain, and nothing seemed to work. I told myself I would try one last thing before calling it quits and taking that leap off the proper rooftop: ketamine infusions…Motherboard

2017-02-22T21:50:38+00:00

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

Abstract

OBJECTIVE:

Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression…NCBI

2017-02-22T21:47:29+00:00

Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment-resistant bipolar depression. The present study sought to replicate this finding in an independent sample… Biological Psychiatry

2017-02-22T18:38:20+00:00

What It’s Like to Have Your Severe Depression Treated With a Hallucinogenic Drug

Everyone’s depression is different, but Ted, a 40-year-old resident of Portland, Oregon, describes his as a “continuous dark veil — a foul, dark, awful perspective that informs every moment of your whole life.” He’d tried to treat it with antidepressants, therapy, visits to psychiatrists, “the whole nine,” but although the antidepressants kept him functional… Science of US

2017-02-22T20:41:39+00:00